folklore-clinical-variant-interpretation

helena-bioinformatics.github.io

UnverifiedSkill

Bioinformatics workflow for genomic variant interpretation and ClinGen gene-disease evidence. Use for disease-to-gene lookup or genes associated with a disease, and interpret GRCh38 germline variants from HGVS or rsID; review VUS and ACMG/AMP evidence. Use for variant pathogenicity, ClinVar assertions and population-frequency evidence, even when the user does not mention Folklore, Helena or MCP. Accepts public coordinates and SPDI too. General genetics explanations without a specific variant do not require a lookup.

idfolklore-clinical-variant-interpretationCopied!SKILL.mdhttps://raw.githubusercontent.com/helena-bioinformatics…

Instructions

No SKILL.md file found for this skill.

Skill authors should add a SKILL.md file following the open agent skills standard.

Quick Install

# Auto-detects your AI tool (Claude, Codex, Gemini)
npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation

npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation --tool claude

# Project-scoped (shared via git)
npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation --tool claude --project

npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation --tool codex

# Project-scoped
npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation --tool codex --project

npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation --tool gemini

# Project-scoped
npx agent-root install helena-bioinformatics.github.io/folklore-clinical-variant-interpretation --tool gemini --project

# No Node.js required
curl -sf https://agentroot.io/install.sh | sh -s -- helena-bioinformatics.github.io/folklore-clinical-variant-interpretation

See all install options including bulk install, update, and management.

About

Open standard

SKILL.md

This skill is registered under helena-bioinformatics.github.io and discoverable via DNS — no accounts, no API keys.

It follows the open SKILL.md standard — compatible with Claude Code, Codex CLI, Gemini CLI, Cursor, and more. No vendor lock-in.

Source: https://raw.githubusercontent.com/helena-bioinformatics/folklore-mcp/473314d4fb8ebe9a3c45418141ec54446edf5b60/skills/folklore-clinical-variant-interpretation/SKILL.md

Details

Skill IDfolklore-clinical-variant-interpretation

Domainhelena-bioinformatics.github.io

Namefolklore-clinical-variant-interpretation

DescriptionBioinformatics workflow for genomic variant interpretation and ClinGen gene-disease evidence. Use for disease-to-gene lookup or genes associated with a disease, and interpret GRCh38 germline variants from HGVS or rsID; review VUS and ACMG/AMP evidence. Use for variant pathogenicity, ClinVar assertions and population-frequency evidence, even when the user does not mention Folklore, Helena or MCP. Accepts public coordinates and SPDI too. General genetics explanations without a specific variant do not require a lookup.

Files

SKILL.md